Firearms that are specifically designed and rated for +P ammunition can safely handle the increased pressure and energy of such cartridges. Many modern handguns, particularly those chambered in common self-defense calibers, have versions or variants that are explicitly designated for +P ammunition. Some firearms manufacturers mark their models with a "+P" designation to indicate their compatibility with these higher-pressure loads.

It is important to consult the manufacturer's specifications, owner's manual, or official documentation to determine if a specific firearm is rated for +P ammunition. The manufacturer's guidelines will provide information on whether the firearm can handle the increased pressures, how frequently +P ammunition can be used, and any other relevant considerations.

In general, firearms chambered in popular self-defense calibers such as 9mm, .40 S&W, and .45 ACP often have models or variants that are designed for +P ammunition. Additionally, certain revolver models chambered in .38 Special or .357 Magnum may also be rated for +P ammunition.

It is crucial to adhere to the manufacturer's recommendations and guidelines regarding the use of +P ammunition to ensure safe and reliable operation of the firearm. If in doubt, it is best to consult with the firearm manufacturer or a qualified gunsmith for specific information on the compatibility of a particular firearm with +P ammunition.